Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation 
Model and Highlights Molecular Regulators of Memory Development

Durek, Pawel; Nordström, Karl; Gasparoni, Gilles; Salhab, Abdulrahman; Kressler, Christopher; de Almeida, Melanie; Bassler, Kevin; Ulas, Thomas; Schmidt, Florian; Xiong, Jieyi; Glažar, Petar; Klironomos, Filippos; Sinha, Anupam; Kinkley, Sarah; Yang, Xinyi; Arrigoni, Laura; Amirabad, Azim Dehghani; Ardakani, Fatemeh Behjati; Feuerbach, Lars; Gorka, Oliver; Ebert, Peter; Müller, Fabian; Li, Na; Frischbutter, Stefan; Schlickeiser, Stephan; Cendon, Carla; Fröhler, Sebastian; Felder, Bärbel; Gasparoni, Nina; Imbusch, Charles D.; Hutter, Barbara; Zipprich, Gideon; Tauchmann, Yvonne; Reinke, Simon; Wassilew, Georgi; Hoffmann, Ute; Richter, Andreas S.; Sieverling, Lina; Consortium, DEEP; Chang, Hyun-Dong; Syrbe, Uta; Kalus, Ulrich; Eils, Jürgen; Brors, Benedikt; Manke, Thomas; Ruland, Jürgen; Lengauer, Thomas; Rajewsky, Nikolaus; Chen, Wei; Dong, Jun; Sawitzki, Birgit; Chung, Ho-Ryun; Rosenstiel, Philip; Schulz, Marcel H.; Schultze, Joachim L.; Radbruch, Andreas; Walter, Jörn; Hamann, Alf; Polansky, Julia K.

doi:10.1016/j.immuni.2016.10.022

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Epigenomic Profiling of Human CD4⁺ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

Durek, P., Nordström, K., Gasparoni, G., Salhab, A., Kressler, C., de Almeida, M., et al. (2016). Epigenomic Profiling of Human CD4⁺ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development. Immunity, 45, 1148-1161. doi:10.1016/j.immuni.2016.10.022.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-AF37-7 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0008-9B03-6

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https://www.sciencedirect.com/science/article/pii/S1074761316304332?via%3Dihub (Verlagsversion) Open Access Status unbekannt

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Durek, Pawel¹, Autor
Nordström, Karl¹, Autor
Gasparoni, Gilles¹, Autor
Salhab, Abdulrahman¹, Autor
Kressler, Christopher¹, Autor
de Almeida, Melanie¹, Autor
Bassler, Kevin¹, Autor
Ulas, Thomas¹, Autor
Schmidt, Florian¹, Autor
Xiong, Jieyi¹, Autor
Glažar, Petar¹, Autor
Klironomos, Filippos¹, Autor
Sinha, Anupam¹, Autor
Kinkley, Sarah¹, Autor
Yang, Xinyi¹, Autor
Arrigoni, Laura¹, Autor
Amirabad, Azim Dehghani¹, Autor
Ardakani, Fatemeh Behjati¹, Autor
Feuerbach, Lars¹, Autor
Gorka, Oliver¹, Autor
Ebert, Peter¹, AutorMüller, Fabian¹, AutorLi, Na¹, AutorFrischbutter, Stefan¹, AutorSchlickeiser, Stephan¹, AutorCendon, Carla¹, AutorFröhler, Sebastian¹, AutorFelder, Bärbel¹, AutorGasparoni, Nina¹, AutorImbusch, Charles D.¹, AutorHutter, Barbara¹, AutorZipprich, Gideon¹, AutorTauchmann, Yvonne¹, AutorReinke, Simon¹, AutorWassilew, Georgi¹, AutorHoffmann, Ute¹, AutorRichter, Andreas S.¹, AutorSieverling, Lina¹, AutorConsortium, DEEP¹, AutorChang, Hyun-Dong¹, AutorSyrbe, Uta¹, AutorKalus, Ulrich¹, AutorEils, Jürgen¹, AutorBrors, Benedikt¹, AutorManke, Thomas², AutorRuland, Jürgen¹, AutorLengauer, Thomas¹, AutorRajewsky, Nikolaus¹, AutorChen, Wei¹, AutorDong, Jun¹, AutorSawitzki, Birgit¹, AutorChung, Ho-Ryun¹, AutorRosenstiel, Philip¹, AutorSchulz, Marcel H.¹, AutorSchultze, Joachim L.¹, AutorRadbruch, Andreas¹, AutorWalter, Jörn¹, AutorHamann, Alf¹, AutorPolansky, Julia K.¹, Autor mehr..

Affiliations:
1External Organizations, ou_persistent22
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640

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Zusammenfassung: The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined. We generated deep epigenomes comprising genome-wide profiles of DNA methylation, histone modifications, DNA accessibility, and coding and non-coding RNA expression in naive, central-, effector-, and terminally differentiated CD45RA⁺ CD4⁺ Tmem cells from blood and CD69⁺ Tmem cells from bone marrow (BM-Tmem). We observed a progressive and proliferation-associated global loss of DNA methylation in heterochromatic parts of the genome during Tmem cell differentiation. Furthermore, distinct gradually changing signatures in the epigenome and the transcriptome supported a linear model of memory development in circulating T cells, while tissue-resident BM-Tmem branched off with a unique epigenetic profile. Integrative analyses identified candidate master regulators of Tmem cell differentiation, including the transcription factor FOXP1. This study highlights the importance of epigenomic changes for Tmem cell biology and demonstrates the value of epigenetic data for the identification of lineage regulators.

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Sprache(n): eng - English

Datum: Erschienen: 2016-11-15

Publikationsstatus: Erschienen

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Art der Begutachtung: Expertenbegutachtung

Identifikatoren: DOI: 10.1016/j.immuni.2016.10.022

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Titel: Immunity

Genre der Quelle: Zeitschrift

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Ort, Verlag, Ausgabe: Cambridge, Mass. : Cell Press

Seiten: - Band / Heft: 45 Artikelnummer: - Start- / Endseite: 1148 - 1161 Identifikator: ISSN: 1074-7613
CoNE: https://pure.mpg.de/cone/journals/resource/954925604783

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