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  Reversal learning strategy in adolescence is associated with prefrontal cortex activation

Boehme, R., Lorenz, R., Gleich, T., Romund, L., Pelz, P., Golde, S., Flemming, E., Wold, A., Deserno, L., Behr, J., Raufelder, D., Heinz, A., & Beck, A. (2017). Reversal learning strategy in adolescence is associated with prefrontal cortex activation. European Journal of Neuroscience, 45(1), 129-137. doi:10.1111/ejn.13401.

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基本情報

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002B-8672-3 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-36E0-9
資料種別: 学術論文

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関連URL

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URL:
https://doi.org/10.1111/ejn.13401 (出版社版)
説明:
-
OA-Status:
Green

作成者

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 作成者:
Boehme, Rebecca1, 2, 著者
Lorenz, Robert1, 3, 著者
Gleich, Tobias1, 4, 著者
Romund, Lydia1, 著者
Pelz, Patricia1, 著者
Golde, Sabrina1, 著者
Flemming, Eva1, 著者
Wold, Andrew2, 著者
Deserno, Lorenz1, 5, 6, 著者           
Behr, Joachim1, 7, 8, 著者
Raufelder, Diana9, 著者
Heinz, Andreas1, 著者
Beck, Anne1, 著者
所属:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Center for Social and Affective Neuroscience, Linköping University, Sweden, ou_persistent22              
3Center for Adaptive Rationality, Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
4NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
6Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
7Institute for Neurophysiology, Charité University Medicine Berlin, Germany, ou_persistent22              
8Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical School Brandenburg, Neuruppin, Germany, ou_persistent22              
9Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              

内容説明

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キーワード: Adolescents; Prediction error; Prefrontal cortex; Reversal learning
 要旨: Adolescence is a critical maturation period for human cognitive control and executive function. In this study, a large sample of adolescents (n = 85) performed a reversal learning task during functional magnetic resonance imaging. We analyzed behavioral data using a reinforcement learning model to provide individually fitted parameters and imaging data with regard to reward prediction errors (PE). Following a model-based approach, we formed two groups depending on whether individuals tended to update expectations predominantly for the chosen stimulus or also for the unchosen one. These groups significantly differed in their problem behavior score obtained using the child behavior checklist (CBCL) and in a measure of their developmental stage. Imaging results showed that dorsolateral striatal areas covaried with PE. Participants who relied less on learning based on task structure showed less prefrontal activation compared with participants who relied more on task structure. An exploratory analysis revealed that PE-related activity was associated with pubertal development in prefrontal areas, insula and anterior cingulate. These findings support the hypothesis that the prefrontal cortex is implicated in mediating flexible goal-directed behavioral control.

資料詳細

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言語: eng - English
 日付: 2016-08-242016-04-052016-09-122016-09-152017-01
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1111/ejn.13401
PMID: 27628616
その他: Epub 2016
 学位: -

関連イベント

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訴訟

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Project information

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Project name : -
Grant ID : II/84 452
Funding program : -
Funding organization : Volkswagen Foundation
Project name : -
Grant ID : 01ZX1311E
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)
Project name : Atherosklerose: Mechanismen und Netzwerke neuer therapeutischer Zielstrukturen / SFB 1123
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : Lern- und Gewöhnungsprozesse als Prädiktoren für die Entwicklung und Aufrechterhaltung alkoholbezogener Störungen / FOR 1617
Grant ID : 2597/13‐1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

出版物 1

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出版物名: European Journal of Neuroscience
  その他 : Eur. J. Neurosci
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
ページ: - 巻号: 45 (1) 通巻号: - 開始・終了ページ: 129 - 137 識別子（ISBN, ISSN, DOIなど）: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988