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  Novel genetic loci underlying human intracranial volume identified through genome-wide association

Adams, H. H. H., Hibar, D. P., Chouraki, V., Stein, J. L., Nyquist, P., Renteria, M. E., Trompet, S., Arias-Vasquez, A., Seshadri, S., Desrivières, S., Beecham, A. H., Jahanshad, N., Wittfeld, K., Van der Lee, S. J., Abramovic, L., Alhusaini, S., Amin, N., Andersson, M., Arfanakis, K. A., Aribisala, B. S., Armstrong, N. J., Athanasiu, L., Axelsson, T., Beiser, A., Bernard, M., Bis, J. C., Blanken, L. M. E., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chauhan, G., Chen, Q., Ching, C. R. K., Cuellar-Partida, G., Den Braber, A., Doan, N. T., Ehrlich, S., Filippi, I., Ge, T., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Greven, C. U., Grimm, O., Griswold, M. E., Guadalupe, T., Hass, J., Haukvik, U. K., Hilal, S., Hofer, E., Höhn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Karbalai, N., Kasperaviciute, D., Kim, S., Klein, M., Krämer, B., Lee–, P. H., Liao, J., Liewald, D. C. M., Lopez, L. M., Luciano, M., Macare, C., Marquand, A., Matarin, M., Mather, K. A., Mattheisen, M., Mazoyer, B., McKay, D. R., McWhirter, R., Milaneschi, Y., Muetzel, R. L., Muñoz Maniega, S., Nho, K., Nugent, A. C., Olde Loohuis, L. M., Oosterlaan, J., Papmeyer, M., Pappa, I., Pirpamer, L., Pudas, S., Pütz, B., Rajan, K. B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-Santiañez, R., Rommelse, N., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Thomson, R., Tordesillas-Gutierrez, D., Toro, R., Trabzuni, D., Vaidya, D., Van der Grond, J., Van der Meer, D., Van Donkelaar, M. M. J., Van Eijk, K. R., VanErp, T. G. M., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Woldehawariat, G., Wolf, C., Wolfers, T., Xu, B., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Aggarwal, N. T., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, J. T., Becker, D. M., Bennett, D. A., Blangero, J., Van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Chen, C., Cheng, C.-Y., Cichon, S., Cookson, M. R., Corvin, A., Crespo-Facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Geus, E. J. C., De Jager, P. L., De Zubicaray, G. I., Delanty, N., Depondt, C., DeStefano, A., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Erk, S., Espeseth, T., Evans, D. A., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Grabe, H. J., Green, R. C., Gruber, O., Guelfi, S., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B.-C., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J.-J., Hulshoff Pol, H. E., Ikeda, M., Ikram, M. K., Jack Jr, C. R., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Launer, L. J., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Longstreth Jr, W. T., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J.-L., Mattay, V. S., McDonald, C., McIntosh, A. M., McMahon, F. J., McMahon, K. L., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-Myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-Seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schofield, P. R., Sigursson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Srikanth, V., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Tiemeier, H., Toga, A. W., Traynor, B., Troncoso, J., Turner, J. A., Tzourio, C., Uitterlinden, A. G., Valdés Hernández, M. C., Van der Brug, M., Van der Lugt, A., Van der Wee, N. J. A., Van Duijn, C. M., Van Haren, N. E. M., Van 't Ent, D., Van Tol, M.-J., Vardarajan, B. N., Veltman, D. J., Vernooij, M. W., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, R. H., Zonderman, A. B., the Alzheimer's Disease Neuroimaging Initiative, EPIGEN, IMAGEN, SYS, Deary, I. J., DeCarli, C., Schmidt, H., Martin, N. G., De Craen, A. J. M., Wright, M. J., Gudnason, V., Schumann, G., Fornage, M., Franke, B., Debette, S., Medland, S. E., Ikram, M. A., & Thompson, P. M. (2016). Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience, 19, 1569-1582. doi:10.1038/nn.4398.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002B-7F28-6 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0003-4A1E-A
資料種別: 学術論文

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https://hdl.handle.net/11858/00-001M-0000-002C-2A97-4
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Adams_etal_2016.pdf
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 作成者:
Adams, Hieab H. H.1, 著者
Hibar, Derrek P.2, 著者
Chouraki, Vincent3, 4, 著者
Stein, Jason L.2, 5, 著者
Nyquist, Paul6, 著者
Renteria, Miguel E.7, 著者
Trompet, Stella8, 著者
Arias-Vasquez, Alejandro9, 著者
Seshadri, Sudha3, 著者
Desrivières, Sylvane10, 著者
Beecham, Ashley H.11, 著者
Jahanshad, Neda2, 著者
Wittfeld, Katharina12, 著者
Van der Lee, Sven J.1, 著者
Abramovic, Lucija13, 著者
Alhusaini, Saud14, 著者
Amin, Najaf1, 著者
Andersson, Micael15, 著者
Arfanakis, Konstantinos A.16, 17, 著者
Aribisala, Benjamin S.18, 19, 著者
Armstrong, Nicola J.20, 21, 著者Athanasiu, Lavinia22, 著者Axelsson, Tomas23, 著者Beiser, Alexa3, 著者Bernard, Manon24, 著者Bis, Joshua C.25, 著者Blanken, Laura M. E.1, 著者Blanton, Susan H.11, 著者Bohlken, Marc M.13, 著者Boks, Marco P.13, 著者Bralten, Janita9, 著者Brickman, Adam M.26, 著者Carmichael, Owen5, 著者Chakravarty, M. Mallar14, 27, 著者Chauhan, Ganesh28, 著者Chen, Qiang29, 著者Ching, Christopher R. K.2, 5, 著者Cuellar-Partida, Gabriel6, 著者Den Braber, Anouk 30, 著者Doan, Nhat Trung22, 著者Ehrlich, Stefan31, 32, 著者Filippi, Irina28, 著者Ge, Tian32, 33, 著者Giddaluru, Sudheer34, 著者Goldman, Aaron L.29, 著者Gottesman, Rebecca F.6, 著者Greven, Corina U.9, 10, 著者Grimm, Oliver35, 著者Griswold, Michael E.36, 著者Guadalupe, Tulio37, 38, 著者           Hass, Johanna31, 著者Haukvik, Unn K.20, 39, 著者Hilal, Saima40, 著者Hofer, Edith41, 著者Höhn, David42, 著者Holmes, Avram J.32, 43, 著者Hoogman, Martine9, 著者Janowitz, Deborah12, 著者Jia, Tianye10, 著者Karbalai, Nazanin42, 著者Kasperaviciute, Dalia44, 45, 著者Kim, Sungeun46, 著者Klein, Marieke9, 著者Krämer, Bernd47, 著者Lee–, Phil H.32, 著者Liao, Jiemin48, 著者Liewald, David C. M.18, 著者Lopez, Lorna M.18, 著者Luciano, Michelle18, 著者Macare, Christine10, 著者Marquand, Andre9, 著者Matarin, Mar44, 著者Mather, Karen A.20, 著者Mattheisen, Manuel49, 著者Mazoyer, Bernard28, 著者McKay, David R.43, 著者McWhirter, Rebekah50, 著者Milaneschi, Yuri30, 著者Muetzel, Ryan L.1, 著者Muñoz Maniega, Susanna 17, 18, 19, 著者Nho, Kwangsik46, 著者Nugent, Allison C.51, 著者Olde Loohuis, Loes M.5, 著者Oosterlaan, Jaap30, 著者Papmeyer, Martina18, 52, 著者Pappa, Irene1, 著者Pirpamer, Lukas41, 著者Pudas, Sara15, 著者Pütz, Benno42, 著者Rajan, Kumar B.17, 著者Ramasamy, Adaikalavan10, 44, 53, 著者Richards, Jennifer S.9, 著者Risacher, Shannon L.46, 著者Roiz-Santiañez, Roberto54, 著者Rommelse, Nanda9, 著者Rose, Emma J.55, 著者Royle, Natalie A.18, 著者Rundek, Tatjana11, 著者Sämann, Philipp G.41, 著者Satizabal, Claudia L.3, 著者Schmaal, Lianne30, 著者Schork, Andrew J.5, 著者Shen, Li46, 著者Shin, Jean24, 著者Shumskaya, Elena9, 著者Smith, Albert V.56, 著者Sprooten, Emma18, 43, 著者Strike, Lachlan T.57, 著者Teumer, Alexander12, 著者Thomson, Russell50, 著者Tordesillas-Gutierrez, Diana54, 著者Toro, Roberto58, 著者Trabzuni, Daniah44, 59, 著者Vaidya, Dhananjay6, 著者Van der Grond, Jeroen 8, 著者Van der Meer, Dennis 60, 著者Van Donkelaar, Marjolein M. J.9, 著者           Van Eijk, Kristel R.13, 著者VanErp, Theo G. M.5, 著者Van Rooij, Daan 9, 60, 著者Walton, Esther31, 著者Westlye, Lars T.22, 著者Whelan, Christopher D.2, 著者Windham, Beverly G.36, 著者Winkler, Anderson M.43, 著者Woldehawariat, Girma51, 著者Wolf, Christiane42, 著者Wolfers, Thomas9, 著者Xu, Bing10, 著者Yanek, Lisa R.6, 著者Yang, Jingyun17, 著者Zijdenbos, Alex61, 著者Zwiers, Marcel P.9, 62, 著者Agartz, Ingrid22, 39, 63, 著者Aggarwal, Neelum T.17, 著者Almasy, Laura64, 著者Ames, David65, 著者Amouyel, Philippe4, 著者Andreassen, Ole A.22, 著者Arepalli, Sampath51, 著者Assareh, Amelia A.20, 著者Barral, Sandra5, 著者Bastin, Mark E.18, 著者Becker, James T.66, 著者Becker, Diane M.59, 著者Bennett, David A.17, 著者Blangero, John63, 著者Van Bokhoven, Hans9, 著者Boomsma, Dorret I.30, 著者Brodaty, Henry20, 著者Brouwer, Rachel M.13, 著者Brunner, Han G.9, 67, 著者Buckner, Randy L.32, 33, 著者Buitelaar, Jan K.9, 著者Bulayeva, Kazima B.68, 著者Cahn, Wiepke13, 著者Calhoun, Vince D.69, 著者Cannon, Dara M.51, 70, 著者Cavalleri, Gianpiero L.55, 著者Chen, Christopher40, 著者Cheng, Ching-Yu48, 著者Cichon, Sven71, 72, 73, 著者Cookson, Mark R51, 著者Corvin, Aiden55, 著者Crespo-Facorro, Benedicto54, 著者Curran, Joanne E.64, 著者Czisch, Michael42, 著者Dale, Anders M.5, 著者Davies, Gareth E.74, 著者De Geus, Eco J. C.30, 著者De Jager, Philip L.33, 著者De Zubicaray, Greig I.57, 著者Delanty, Norman75, 著者Depondt, Chantal76, 著者DeStefano, Anita3, 著者Dillman, Allissa51, 著者Djurovic, Srdjan22, 34, 著者Donohoe, Gary55, 70, 著者Drevets, Wayne C.51, 著者Duggirala, Ravi64, 著者Dyer, Thomas D.64, 著者Erk, Susanne77, 著者Espeseth, Thomas22, 著者Evans, Denis A.17, 著者Fedko, Iryna O.30, 著者Fernández, Guillén9, 著者Ferrucci, Luigi78, 著者Fisher, Simon E.37, 62, 著者           Fleischman, Debra A.17, 51, 著者Ford, Ian79, 著者Foroud, Tatiana M.46, 著者Fox, Peter T.64, 著者Francks, Clyde37, 62, 80, 著者           Fukunaga, Masaki81, 著者Gibbs, J. Raphael51, 著者Glahn, David C.43, 著者Gollub, Randy L.33, 著者Göring, Harald H. H.64, 著者Grabe, Hans J.12, 82, 著者Green, Robert C.33, 83, 著者Gruber, Oliver47, 著者Guelfi, Sebastian44, 著者Hansell, Narelle K.7, 著者Hardy, John44, 著者Hartman, Catharina A.60, 著者Hashimoto, Ryota84, 著者Hegenscheid, Katrin12, 著者Heinz, Andreas77, 著者Le Hellard, Stephanie34, 著者Hernandez, Dena G.44, 51, 著者Heslenfeld, Dirk J.30, 著者Ho, Beng-Choon85, 著者Hoekstra, Pieter J.60, 著者Hoffmann, Wolfgang12, 著者Hofman, Albert1, 著者Holsboer, Florian42, 86, 著者Homuth, Georg12, 著者Hosten, Norbert12, 著者Hottenga, Jouke-Jan30, 著者Hulshoff Pol, Hilleke E. 13, 著者Ikeda, Masashi87, 著者Ikram, M. Kamran13, 著者Jack Jr, Clifford R.88, 著者Jenkinson, Mark53, 著者Johnson, Robert89, 著者Jönsson, Erik G.22, 63, 著者Jukema, J. Wouter8, 著者Kahn, René S.13, 著者Kanai, Ryota44, 90, 91, 著者Kloszewska, Iwona92, 著者Knopman, David S.88, 著者Kochunov, Peter89, 著者Kwok, John B.20, 93, 著者Launer, Lenore J51, 著者Lawrie, Stephen M.18, 著者Lemaître, Hervé28, 著者Liu, Xinmin51, 94, 著者Longo, Dan L.78, 著者Longstreth Jr, W. T.25, 著者Lopez, Oscar L.66, 著者Lovestone, Simon10, 53, 著者Martinez, Oliver5, 著者Martinot, Jean-Luc95, 著者Mattay, Venkata S.29, 著者McDonald, Colm70, 著者McIntosh, Andrew M.18, 著者McMahon, Francis J.51, 著者McMahon, Katie L.57, 著者Mecocci, Patrizia96, 著者Melle, Ingrid22, 著者Meyer-Lindenberg, Andreas35, 著者Mohnke, Sebastian77, 著者Montgomery, Grant W.7, 著者Morris, Derek W.55, 70, 著者Mosley, Thomas H.36, 著者Mühleisen, Thomas W.72, 73, 著者Müller-Myhsok, Bertram42, 97, 98, 著者Nalls, Michael A.51, 著者Nauck, Matthias12, 著者Nichols, Thomas E.53, 99, 著者Niessen, Wiro J.1, 100, 著者Nöthen, Markus M72, 著者Nyberg, Lars15, 著者Ohi, Kazutaka84, 著者Olvera, Rene L.64, 著者Ophoff, Roel A.5, 13, 著者Pandolfo, Massimo76, 著者Paus, Tomas24, 101, 著者Pausova, Zdenka24, 著者Penninx, Brenda W. J. H.30, 著者Pike, G. Bruce102, 著者Potkin, Steven G.5, 著者Psaty, Bruce M.25, 103, 著者Reppermund, Simone20, 著者Rietschel, Marcella35, 著者Roffman, Joshua L.32, 著者Romanczuk-Seiferth, Nina77, 著者Rotter, Jerome I.5, 著者Ryten, Mina10, 44, 著者Sacco, Ralph L.11, 著者Sachdev, Perminder S.20, 104, 著者Saykin, Andrew J.46, 著者Schmidt, Reinhold41, 著者Schofield, Peter R.20, 93, 著者Sigursson, Sigurdur105, 著者Simmons, Andy10, 著者Singleton, Andrew51, 著者Sisodiya, Sanjay M.44, 著者Smith, Colin18, 著者Smoller, Jordan W.32, 44, 著者Soininen, Hilkka106, 著者Srikanth, Velandai50, 107, 著者Steen, Vidar M.34, 著者Stott, David J.79, 著者Sussmann, Jessika E.18, 著者Thalamuthu, Anbupalam20, 著者Tiemeier, Henning1, 27, 著者Toga, Arthur W.2, 著者Traynor, Bryan52, 著者Troncoso, Juan6, 著者Turner, Jessica A.108, 著者Tzourio, Christophe29, 著者Uitterlinden, Andre G.1, 著者Valdés Hernández, Maria C. 18, 著者Van der Brug, Marcel 109, 著者Van der Lugt, Aad 1, 著者Van der Wee, Nic J. A. 8, 著者Van Duijn, Cornelia M.1, 著者Van Haren, Neeltje E. M.13, 著者Van 't Ent, Dennis 31, 著者Van Tol, Marie-Jose 60, 著者Vardarajan, Badri N.27, 著者Veltman, Dick J.31, 著者Vernooij, Meike W.1, 著者Völzke, Henry12, 著者Walter, Henrik78, 著者Wardlaw, Joanna M.18, 著者Wassink, Thomas H.85, 著者Weale, Michael E.10, 著者Weinberger, Daniel R.6, 30, 著者Weiner, Michael W.5, 著者Wen, Wei20, 著者Westman, Eric63, 著者White, Tonya1, 94, 著者Wong, Tien Y.40, 48, 著者Wright, Clinton B.11, 著者Zielke, Ronald H.89, 著者Zonderman, Alan B.51, 著者the Alzheimer's Disease Neuroimaging Initiative, EPIGEN, IMAGEN, SYS, 著者              Deary, Ian J.18, 著者DeCarli, Charles5, 著者Schmidt, Helena41, 著者Martin, Nicholas G.7, 著者De Craen, Anton J. M.8, 著者Wright, Margaret J.7, 57, 著者Gudnason, Vilmundur56, 105, 著者Schumann, Gunter10, 著者Fornage, Myriam64, 著者Franke, Barbara9, 著者Debette, Stéphanie3, 28, 著者Medland, Sarah E.7, 著者Ikram, M Arfan1, 著者Thompson, Paul M.2, 著者 全て表示
所属:
1Erasmus MC, Rotterdam, The Netherlands, ou_persistent22              
2University of Southern California, Marina del Rey, California, USA, ou_persistent22              
3Boston University, Boston, Massachusetts, USA, ou_persistent22              
4Lille University, Lille, France, ou_persistent22              
5University of California, Los Angeles, California, USA, ou_persistent22              
6Johns Hopkins, Baltimore, Maryland, USA, ou_persistent22              
7Berghofer Medical Research Institute, Brisbane, Australia, ou_persistent22              
8Leiden University, Leiden, The Netherlands, ou_persistent22              
9Radboud University, Nijmegen, The Netherlands, ou_persistent22              
10King's College London, London, UK, ou_persistent22              
11University of Miami, Miami, Florida, USA, ou_persistent22              
12University of Greifswald, Greifswald, Germany, ou_persistent22              
13University of Utrecht, Utrecht, The Netherlands, ou_persistent22              
14McGill University, Montreal, Canada, ou_persistent22              
15Umea University, Umea, Sweden, ou_persistent22              
16Illinois Institute of Technology, Chicago, Illinois, USA, ou_persistent22              
17Rush University, Chicago, Illinois, USA, ou_persistent22              
18University of Edinburgh, Edinburgh, UK, ou_persistent22              
19Lagos State University, Lagos, Nigeria, ou_persistent22              
20University of New South Wales, Sydney, Australia, ou_persistent22              
21Murdoch University, Perth, Australia, ou_persistent22              
22University of Oslo, Oslo, Norway, ou_persistent22              
23Uppsala University, Uppsala, Sweden, ou_persistent22              
24University of Toronto, Toronto, Canada, ou_persistent22              
25University of Washington, Seattle, Washington, USA, ou_persistent22              
26Columbia University Medical Center, New York, NY, USA, ou_persistent22              
27Douglas Mental Health University, Montreal, Canada, ou_persistent22              
28University of Bordeaux, Bordeaux, France, ou_persistent22              
29Lieber Institute for Brain Development, Baltimore, Maryland, USA, ou_persistent22              
30VU University, Amsterdam, The Netherlands, ou_persistent22              
31TU Dresden, Dresden, Germany, ou_persistent22              
32Massachusetts General Hospital, Boston, Massachusetts, ou_persistent22              
33Harvard University, Boston, Massachusetts, USA, ou_persistent22              
34University of Bergen, Bergen, Norway, ou_persistent22              
35University Heidelberg, Heidelberg, Germany, ou_persistent22              
36University of Mississippi, ou_persistent22              
37Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
38International Max Planck Research School for Language Sciences, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL, ou_1119545              
39Diakonhjemmet Hospital, Oslo, Norway, ou_persistent22              
40National University Singapore, Singapore, ou_persistent22              
41Medical University Graz, Graz, Austria, ou_persistent22              
42Max Planck Institute of Psychiatry, Munich, Germany, ou_persistent22              
43Yale University, New Haven, Connecticut, USA, ou_persistent22              
44University College London, London, UK, ou_persistent22              
45Epilepsy Society, London, UK, ou_persistent22              
46Indiana University School of Medicine, Indianapolis, Indiana, USA, ou_persistent22              
47Georg-August-University, Goettingen, Germany, ou_persistent22              
48Singapore National Eye Centre, ou_persistent22              
49Aarhus University, Aarhus, Denmark, ou_persistent22              
50University of Tasmania, Hobart, Tasmania, Australia, ou_persistent22              
51National Institute of Health, Bethesda, Maryland, USA, ou_persistent22              
52University of Bern, Bern, Switzerland, ou_persistent22              
53University of Oxford, Oxford, UK, ou_persistent22              
54University of Cantabria, Santander, Spain, ou_persistent22              
55Trinity College Dublin, Dublin, Ireland, ou_persistent22              
56University of Iceland, Reykjavik, Iceland, ou_persistent22              
57University of Queensland, Brisbane, Australia, ou_persistent22              
58Institut Pasteur, Paris, France, ou_persistent22              
59King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia, ou_persistent22              
60University of Groningen, Groningen, The Netherlands, ou_persistent22              
61Biospective Inc., Motreal, Quebec, Canada, ou_persistent22              
62Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
63Karolinska Institutet, Stockholm, Sweden, ou_persistent22              
64University of Texas, San Antonio, USA, ou_persistent22              
65University of Melbourne, Melbourne, Australia, ou_persistent22              
66University of Pittsburgh, Pittsburgh, Pennsylvania, USA, ou_persistent22              
67University of Maastricht, Maastricht, The Netherlands, ou_persistent22              
68Russian Academy of Sciences, Moscow, Russia, ou_persistent22              
69University of New Mexico, Albuquerque, New Mexico, USA, ou_persistent22              
70National University of Ireland, Galway, Ireland, ou_persistent22              
71University of Basel, Basel, Switzerland, ou_persistent22              
72University of Bonn, Bonn, Germany, ou_persistent22              
73Research Centre Jülich, Jülich, Germany, ou_persistent22              
74Avera Institute for Human Genetics, Sioux Falls, South Dakota, USA, ou_persistent22              
75Beaumont Hospital, Dublin, Ireland, ou_persistent22              
76Universite Libre de Bruxelles, Bruxelles, Belgium, ou_persistent22              
77Charité - Universitätsmedizin Berlin, Berlin, Germany, ou_persistent22              
78National Institute on Aging, Baltimore, Maryland, USA, ou_persistent22              
79University of Glasgow, Glasgow, UK, ou_persistent22              
80Imaging Genomics, MPI for Psycholinguistics, Max Planck Society, Wundtlaan 1, 6525 XD Nijmegen, NL, ou_2579692              
81National Institute for Physiological Sciences, Aichi, Japan, ou_persistent22              
82HELIOS hospital Stralsund, Stralsund, Germany, ou_persistent22              
83Brigham and Women's Hospital, Boston, Massachusetts, USA, ou_persistent22              
84Osaka University, Osaka, Japan, ou_persistent22              
85University of Iowa, Iowa City, USA, ou_persistent22              
86HMNC Brain Health, Munich, Germany, ou_persistent22              
87Fujita Health University School of Medicine, Toyoake, Japan, ou_persistent22              
88Mayo Clinic, Rochester, Minnesota, USA, ou_persistent22              
89University of Maryland , Baltimore, Maryland, USA, ou_persistent22              
90University of Sussex, Brighton, UK , ou_persistent22              
91Araya Brain Imaging, Tokyo, Japan, ou_persistent22              
92Medical University of Lodz, Lodz, Poland, ou_persistent22              
93Neuroscience Research Australia, Sydney, Australia, ou_persistent22              
94Columbia University, New York, USA, ou_persistent22              
95University Paris Sud, Paris, France, ou_persistent22              
96University of Perugia, Perugia, Italy, ou_persistent22              
97Munich Cluster for Systems Neurology (SyNergy), Munich, Germany, ou_persistent22              
98University of Liverpool, Liverpool, UK, ou_persistent22              
99University of Warwick, Coventry, UK, ou_persistent22              
100Delft University of Technology, Delft, The Netherlands, ou_persistent22              
101Child Mind Institute, New York, New York, USA, ou_persistent22              
102University of Calgary, Calgary, Canada, ou_persistent22              
103Group Health Research Institute, Seattle, Washington, USA, ou_persistent22              
104Prince of Wales Hospital, Sydney, Australia, ou_persistent22              
105Icelandic Heart Association, Kopavogur, Iceland, ou_persistent22              
106University of Eastern Finland, Kuopio, Finland, ou_persistent22              
107Monash University, Melbourne, Australia, ou_persistent22              
108Georgia State University, Atlanta, Georgia, USA, ou_persistent22              
109Genentech Inc., South San Francisco, California, USA , ou_persistent22              

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 要旨: Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late
life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438
adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were
also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height.
We found a high genetic correlation with child head circumference (genetic = 0.748), which indicates a similar genetic
background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial
volume were also related to childhood and adult cognitive function, and Parkinson’s disease, and were enriched near genes
involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial
volume and provide genetic support for theories on brain reserve and brain overgrowth.

資料詳細

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言語: eng - English
 日付: 20162016-10-032016
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1038/nn.4398
 学位: -

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出版物 1

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出版物名: Nature Neuroscience
  その他 : Nat. Neurosci.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: New York, NY : Nature America Inc.
ページ: - 巻号: 19 通巻号: - 開始・終了ページ: 1569 - 1582 識別子（ISBN, ISSN, DOIなど）: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931