Plasma membrane reorganization: A glycolipid gateway for microbes

Aigal, Sahaja; Claudinon, Julie; Römer, Winfried

doi:doi: 10.1016/j.bbamcr.2014.11.014

Plasma membrane reorganization: A glycolipid gateway for microbes

Aigal, S., Claudinon, J., & Römer, W. (2015). Plasma membrane reorganization: A glycolipid gateway for microbes. Biochimica et Biophysica Acta-Molecular Cell Research, 1853, 858-871. doi:doi: 10.1016/j.bbamcr.2014.11.014.

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アイテムのパーマリンク: https://hdl.handle.net/someHandle/test/escidoc:904164 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002B-99B2-B

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Aigal, Sahaja^{1, 2, 3}, 著者
Claudinon, Julie^{1, 2}, 著者
Römer, Winfried^{1, 2}, 著者

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1Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany, ou_persistent22
2BIOSS Centre for Biological Signaling Studies, Albert-Ludwigs-University Freiburg, Freiburg, Germany, ou_persistent22
3Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640

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要旨: Ligand-receptor interactions, which represent the core for cell signaling and internalization processes are largely affected by the spatial configuration of host cell receptors. There is a growing piece of evidence that receptors are not homogeneously distributed within the plasma membrane, but are rather pre-clustered in nanodomains, or clusters are formed upon ligand binding. Pathogens have evolved many strategies to evade the host immune system and to ensure their survival by hijacking plasma membrane receptors that are most often associated with lipid rafts. In this review, we discuss the early stage molecular and physiological events that occur following ligand binding to host cell glycolipids. The ability of various biological ligands (e.g. toxins, lectins, viruses or bacteria) that bind to glycolipids to induce their own uptake into mammalian cells by creating negative membrane curvature and membrane invaginations is explored. We highlight recent trends in understanding nanoscale plasma membrane (re-)organization and present the benefits of using synthetic membrane systems. This article is part of a Special Issue entitled: Nanoscale membrane organisation and signalling.

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言語: eng - English

日付: 出版: 2015-04

出版の状態: 出版

ページ: 14

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査読: 査読あり

識別子（DOI, ISBNなど）: DOI: doi: 10.1016/j.bbamcr.2014.11.014

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出版物名: Biochimica et Biophysica Acta-Molecular Cell Research

種別: 学術雑誌

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出版社, 出版地: New York, NY : Elsevier

ページ: 14 巻号: 1853 通巻号: - 開始・終了ページ: 858 - 871 識別子（ISBN, ISSN, DOIなど）: その他: 954926938702
ISSN: 0167-4889
CoNE: https://pure.mpg.de/cone/journals/resource/954926938702_4

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