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  Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

Hernandez, P. P., Mahlakoiv, T., Yang, I., Schwierzeck, V., Nguyen, N., Guendel, F., Gronke, K., Ryffel, B., Hölscher, C., Dumoutier, L., Renauld, J.-C., Suerbaum, S., Staehli, P., & Diefenbach, A. (2015). Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection. Nature Immunology, 16, 698-707. doi:DOI: 10.1038/ni.3180.

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資料種別: 学術論文

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 作成者:
Hernandez, Pedro P.1, 2, 3, 著者
Mahlakoiv, Tanel4, 5, 著者
Yang, Ines6, 7, 著者
Schwierzeck, Vera1, 2, 著者
Nguyen, Nam2, 著者
Guendel, Fabian1, 2, 8, 著者
Gronke, Konrad1, 2, 3, 8, 著者
Ryffel, Bernhard9, 10, 11, 著者
Hölscher, Christoph12, 13, 著者
Dumoutier, Laure14, 著者
Renauld, Jean-Christophe14, 著者
Suerbaum, Sebastian6, 7, 著者
Staehli, Peter4, 著者
Diefenbach, Andreas1, 2, 8, 著者
所属:
1Research Centre Immunology and Institute of Medical Microbiology and Hygiene, University of Mainz Medical Centre, Mainz, Germany, ou_persistent22              
2Department of Medical Microbiology and Hygiene, Institute for Medical Microbiology and Hygiene, Freiburg University Medical Centre, Freiburg, Germany, ou_persistent22              
3Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
4Department of Medical Microbiology and Hygiene, Institute for Virology, Freiburg University Medical Centre, Freiburg, Germany, ou_persistent22              
5Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany, ou_persistent22              
6Institute of Medical Microbiology and Hospital Epidemiiology, Hannover Medical School, Hannover, Germany, ou_persistent22              
7German Center for Infection Research, Hannover, Germany, ou_persistent22              
8Research Training Group (GRK1104) of Organogenesis , Freiburg, Germany, ou_persistent22              
9INEM-UMR7355, Molecular Immunology, University of Orleans, Orleans, France, ou_persistent22              
10CNRS, Orleans, France, ou_persistent22              
11Institute of Cape Town, Cape Town, South Africa, ou_persistent22              
12Infection Immunology Research, Research Center Borstel, Borstel, Germany, ou_persistent22              
13Cluster of Excellence Inflammation at Interfaces, Borstel-Kiel-Lübeck-Plön, Germany, ou_persistent22              
14Ludwig Institute for Cancer Research, Université Catholique de Louvain, Brussels, Belgium, ou_persistent22              

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 要旨: The epithelium is the main entry point for many viruses, but the processes that protect barrier surfaces against viral infections are incompletely understood. Here we identified interleukin 22 (IL-22) produced by innate lymphoid cell group 3 (ILC3) as an amplifier of signaling via interferon-λ (IFN-λ), a synergism needed to curtail the replication of rotavirus, the leading cause of childhood gastroenteritis. Cooperation between the receptor for IL-22 and the receptor for IFN-λ, both of which were 'preferentially' expressed by intestinal epithelial cells (IECs), was required for optimal activation of the transcription factor STAT1 and expression of interferon-stimulated genes (ISGs). These data suggested that epithelial cells are protected against viral replication by co-option of two evolutionarily related cytokine networks. These data may inform the design of novel immunotherapy for viral infections that are sensitive to interferons.

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言語: eng - English
 日付: 2015-05-25
 出版の状態: 出版
 ページ: 10
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): DOI: DOI: 10.1038/ni.3180
 学位: -

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出版物 1

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出版物名: Nature Immunology
  その他 : Nat. Immunol.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: New York, NY : Nature America Inc.
ページ: 10 巻号: 16 通巻号: - 開始・終了ページ: 698 - 707 識別子(ISBN, ISSN, DOIなど): ISSN: 1529-2908
その他: 974392607073
CoNE: https://pure.mpg.de/cone/journals/resource/974392607073