ausblenden:
Schlagwörter:
Anti-Inflammatory Agents/chemistry/*isolation & purification/*pharmacology
Fabaceae/*chemistry
Glycyrrhiza/metabolism
Molecular Structure
PPAR gamma/*agonists
Receptors, Cytoplasmic and Nuclear/metabolism
Salicylates/chemistry/*isolation & purification/*pharmacology
Stilbenes/chemistry/*isolation & purification/*pharmacology
Tumor Necrosis Factor-alpha/pharmacology
Zusammenfassung:
Amorfrutins are isoprenoid-substituted benzoic acid derivatives, which were found in Amorpha fruticosa L. (bastard indigo) and in Glycyrrhiza foetida Desf. (licorice). Recently, amorfrutins were shown to be selective activators of the nuclear receptor PPARgamma. Here, we investigated the effects and PPARgamma-based mechanisms of reducing inflammation in colon cells by treatment with amorfrutins. In TNF-alpha-stimulated colon cells amorfrutin A (1) reduced significantly the expression and secretion of several inflammation mediators, in part due to interaction with PPARgamma. These results support the hypothesis that amorfrutins may have the potential to treat inflammation disorders such as chronic inflammatory bowel diseases.
