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  Caged progesterone: a new tool for studying rapid nongenomic actions of progesterone

Kilic, F., Kashikar, N., Schmidt, R., Alvarez, L., Dai, L., Weyand, I., et al. (2009). Caged progesterone: a new tool for studying rapid nongenomic actions of progesterone. Journal of the American Chemical Society, 131(11), 4027-4030.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-6213-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-6214-3
Genre: Journal Article

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Kilic-2009-Caged progesterone_.pdf (Any fulltext), 229KB
 
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Kilic, F., Author
Kashikar, N.1, Author           
Schmidt, R., Author
Alvarez, L.1, Author           
Dai, L., Author
Weyand, I., Author
Wiesner, B., Author
Goodwin, N.1, Author           
Hagen, V., Author
Kaupp, U. B.1, Author           
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1Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society, ou_2173679              

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 Abstract: Ketalization of the biomolecule progesterone with (6-bromo-7-hydroxycoumarin-4-yl)ethane-1,2-diol gives the photolabile progesterone derivatives 3 and 4. These compounds display dramatically reduced bioactivity and release progesterone upon irradiation with UV/vis or IR light. In particular, 4 can be used to perform concentration-jump experiments with high temporal and spatial resolution that allows one to study elegantly the mechanisms of rapid nongenomic cellular events evoked by progesterone. The usefulness of 4 was demonstrated by measurement of changes in swimming behavior of single human sperm caused by progesterone-induced Ca2+ influx in the sperm flagellum

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 Dates: 2009
 Publication Status: Issued
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 Identifiers: ISI: ISI:000264792700061
ISSN: 0002-7863
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Title: Journal of the American Chemical Society
  Alternative Title : J. Am. Chem. Soc.
Source Genre: Journal
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Pages: - Volume / Issue: 131 (11) Sequence Number: - Start / End Page: 4027 - 4030 Identifier: -