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  Multi-center mapping of structural network alterations in autism

Valk, S. L., DiMartino, A., Milham, M., & Bernhardt, B. C. (2015). Multi-center mapping of structural network alterations in autism. Human Brain Mapping, 36(6), 2364-2373. doi:10.1002/hbm.22776.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-0027-AD9E-8 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-5B4E-7
資料種別: 学術論文

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関連URL

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URL:
https://doi.org/10.1002/hbm.22776 (出版社版)
説明:
-
OA-Status:
Green

作成者

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 作成者:
Valk, Sofie L.1, 著者           
DiMartino, Adriana2, 著者
Milham, M.ichael3, 4, 著者
Bernhardt, Boris C.1, 5, 著者           
所属:
1Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              
2Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience, New York University Child Study Center, NY, USA, ou_persistent22              
3Child Mind Institute, New York, NY, USA, ou_persistent22              
4Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22              
5McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              

内容説明

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キーワード: ASD; ABIDE; Neocortex; Connectivity; Medial PFC; Connectome
 要旨: Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions primarily characterized by abnormalities in social cognition. Abundant previous functional MRI studies have shown atypical activity in networks encompassing medial prefrontal cortex (mPFC) and medial parietal regions corresponding to posterior cingulate cortex and precuneus (PCC/PCU). Conversely, studies assessing structural brain anomalies in ASD have been rather inconsistent. The current work evaluated whether structural changes in ASD can be reliability detected in a large multicenter dataset. Our comprehensive structural MRI framework encompassed cortical thickness mapping and structural covariance analysis based on three independent samples comprising individuals with ASD and controls (n = 220), selected from the Autism Brain Imaging Data Exchange open-access database. Surface-based analysis revealed increased cortical thickness in ASD relative to controls in mPFC and lateral prefrontal cortex. Clusters encompassing mPFC were embedded in altered inter-regional covariance networks, showing decreased covariance in ASD relative to controls primarily to PCC/PCU and inferior parietal regions. Cortical thickness increases and covariance reductions in ASD were consistent, yet of variable effect size, across the different sites evaluated and measurable both in children and adults. Our multisite study shows regional and network-level structural alterations in mPFC in ASD that, possibly, relate to atypical socio-cognitive functions in this condition.

資料詳細

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言語: eng - English
 日付: 2014-09-042015-02-132015-02-252015-06
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1002/hbm.22776
PMID: 25727858
PMC: PMC6129398
その他: Epub 2015
 学位: -

関連イベント

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訴訟

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Project information

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Project name : -
Grant ID : K01MH081191, K08MH092697, K23MH087770, P50MH060450, R01MH067924, R01MH080826, R01MH081218, R21MH084126
Funding program : -
Funding organization : National Institute of Mental Health (NIMH)
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Funding organization : National Institutes of Health (NIH)
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Grant ID : F31DC010143, T32DC008553
Funding program : -
Funding organization : National Institute on Deafness and Other Communication Disorders (NIDCD)
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Grant ID : R01NS034783
Funding program : -
Funding organization : National Institute of Neurological Disorders and Stroke (NINDS)
Project name : -
Grant ID : P50HD055748, R01HD065282
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Funding organization : National Institute of Child Health and Human Development (NICHD)
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Grant ID : 04593
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Funding organization : Autism Speaks
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Funding program : -
Funding organization : Stavros Niarchos Foundation
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Funding program : -
Funding organization : Leon Levy Foundation
Project name : -
Grant ID : 1677
Funding program : Mentor-based Predoctoral Fellowship
Funding organization : Autism Speaks
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Funding organization : University of Utah Multidisciplinary Research Seed Grant
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Funding organization : Ben B. and Iris M. Margolis Foundation
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Funding program : Jeanne Timmins Costello Award
Funding organization : Montreal Neurological Institute and Hospital
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Funding program : -
Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : -
Grant ID : -
Funding program : International Max Planck Research School Stipend, IMPRS NeuroCom
Funding organization : Max-Planck Society (MPG)

出版物 1

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出版物名: Human Brain Mapping
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: New York : Wiley-Liss
ページ: - 巻号: 36 (6) 通巻号: - 開始・終了ページ: 2364 - 2373 識別子（ISBN, ISSN, DOIなど）: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686