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キーワード:
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要旨:
DNA protein crosslinks (DPCs) are highly toxic DNA lesions because they
interfere with DNA transactions. The recent discovery of a yeast
protease that processes DPCs proteolytically raises the question whether
DPC proteases also exist in higher eukaryotes. We argue here that the
yeast enzyme, Wss1 (weak suppressor of smt3), is a member of a protease
family whose mammalian representative is Spartan (SprT-like
domain-containing protein)/DVC1 (DNA damage protein targeting VCP). DPC
proteases may thus be common to all eukaryotes where they function as
novel guardians of the genome.
