ausblenden:
Schlagwörter:
anticancer agents; enzyme inhibitors; natural products; spiroacetals; structure elucidation
Zusammenfassung:
A subtle difference: A single step suffices to transform a linear precursor into the chromane spiroketal core of the metalloproteinase-3 inhibitor berkelic acid by an acid-catalyzed deprotection/Michael addition/acetalization cascade. This efficient route resulted from the realization that the originally proposed structure is neither thermodynamically nor kinetically favored and has led to revision of the structure.