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Free keywords:
NUCLEAR-MAGNETIC-RESONANCE; MIT UROTROPIN-STRUKTUR; CRYSTAL-STRUCTURE; PLATINUM(II) COMPLEXES; X-RAY; MOLECULAR-STRUCTURE; CLINICAL-EXPERIENCE; DICHLOROPLATINUM(II) COMPLEX; DES 1.3-DIAZA-ADAMANTANS; PALLADIUM(II) COMPLEXES
Abstract:
Bispidine analogues 1−3 of cisplatin, carboplatin, and oxaliplatin have been prepared, including some DMF and water solute complexes. The crystal structures reveal various patterns of N−H···Cl and N−H···O hydrogen bonds. For the hydrates of 1 and 2, different modes of water solvation were found. The compounds have been tested for their cytotoxicity against standard human cancer cell lines, revealing significant cytotoxic activity along with a low platinum resistance factor R.