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  S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum

Steiner, J., Schmitt, A., Schroeter, M. L., Bogerts, B., Falkai, P., Turck, C. W., et al. (2014). S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 264(4), 311-316. doi:10.1007/s00406-014-0490-z.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-C3A1-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0024-C3A2-7
Genre: Journal Article

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 Creators:
Steiner, Johann1, Author
Schmitt, Andrea1, Author
Schroeter, Matthias L.1, Author
Bogerts, Bernhard1, Author
Falkai, Peter1, Author
Turck, Christoph W.2, Author           
Martins-de-Souza, Daniel3, Author           
Affiliations:
1external, ou_persistent22              
2Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              
3Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Abstract: Here we report the downregulation of S100B in the nuclear proteome of the corpus callosum from nine schizophrenia patients compared to seven mentally healthy controls. Our data have been obtained primarily by mass spectrometry and later confirmed by Western blot. This is an intriguing finding coming from a brain region which is essentially composed by white matter, considering the potential role of S100B in the control of oligodendrocyte maturation. This data reinforce the importance of oligodendrocytes in schizophrenia, shedding more light to its pathobiology.

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Language(s): eng - English
 Dates: 2014-02-072014-06
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000339883300005
DOI: 10.1007/s00406-014-0490-z
 Degree: -

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Title: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
Source Genre: Journal
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Publ. Info: Heidelberg : Springer-Verlag
Pages: - Volume / Issue: 264 (4) Sequence Number: - Start / End Page: 311 - 316 Identifier: ISSN: 0940-1334