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キーワード:
Low-Valent Titanium, Enediolates, Coumarins, 2-Quinolones, Aldol condensation
要旨:
Low-valent titanium prepared by the reduction of TiCl3 with zinc dust oxidatively adds to α-ketoamides or α-ketoesters with the formation of the corresponding titanium enediolates. These 1,2-difunctional nucleophiles, which have hardly been used in organic synthesis so far, undergo regioselective intramolecular aldol condensation reactions with various electrophiles such as aldehydes, ketones, nitriles, esters and amides. This methodology allows the synthesis of differently substituted coumarin and 2-quinolone derivatives.
