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キーワード:
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要旨:
The neostriatum is important for the control of movement and certain cognitive functions [1]. Loss of striatal neurons or degeneration of the dopaminergic nigrostriatal pathway leads to devastating neurologic disorders. Recent studies about the reduction of Parkinson symptoms in primats [2,3] demonstrate the value of in vivo study of striatal neurochemistry. Here we present a pilot MRS study in monkeys, in which we conducted in vivo measurements of metabolite concentrations of a 0.7cc voxel positioned in the caudate nucleus of a macaque monkey. Our general aim is to combine this methodology with other invasive techniques, such as microdialysis or electrophysiology in order to couple the macroscopic changes visualized with MRS with their underlying neurophysiological events.
