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  Optical Imaging of the Spatiotemporal Dynamics of Cerebral Blood Flow and Oxidative Metabolism in the Rat Barrel Cortex

Weber, B., Burger, C., Wyss, M., von Schulthess, G., Scheffold, F., & Buck, A. (2004). Optical Imaging of the Spatiotemporal Dynamics of Cerebral Blood Flow and Oxidative Metabolism in the Rat Barrel Cortex. European Journal of Neuroscience: European Neuroscience Association, 20(10), 2664-2670. doi:10.1111/j.1460-9568.2004.03735.x.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-F3D9-4 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0005-504C-C
Genre: Zeitschriftenartikel

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https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1460-9568.2004.03735.x (Verlagsversion)
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 Urheber:
Weber, B1, Autor           
Burger, C, Autor
Wyss, M, Autor
von Schulthess, GK, Autor
Scheffold, F, Autor
Buck, A, Autor
Affiliations:
1External Organizations, ou_persistent22              

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Schlagwörter: -
 Zusammenfassung: Oxidative metabolism and cerebral blood flow (CBF) are two of the most important measures in neuroimaging. However, results from concurrent imaging of the two with high spatial and temporal resolution have never been published. We used flavoprotein autofluorescence (AF) and laser speckle imaging (LSI) in the anaesthetized rat to map oxidative metabolism and CBF in response to single vibrissa stimulation. Autofluorescence responses reflecting oxidative metabolism demonstrated a fast increase with a delay of 0.1 s. The sign‐reversed speckle contrast reflecting CBF started to rise with a delay of 0.6 s and reached its maximum 1.4 s after the stimulation offset. The fractional signal changes were 2.0% in AF and 9.7% in LSI. Pixelwise modelling revealed that CBF maps spread over an area up to 2.5‐times larger than metabolic maps. The results provide evidence that the increase in cerebral oxidative metabolism in response to sensory stimulation is considerably faster and more localized than the CBF response. This suggests that future developments in functional imaging concentrating on the metabolic response promise an increased spatial resolution.

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 Datum: 2004-11
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: BibTex Citekey: 2881
DOI: 10.1111/j.1460-9568.2004.03735.x
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Titel: European Journal of Neuroscience : European Neuroscience Association
  Andere : Eur. J. Neurosci
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
Seiten: - Band / Heft: 20 (10) Artikelnummer: - Start- / Endseite: 2664 - 2670 Identifikator: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988