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  Semi-Supervised Protein Classification using Cluster Kernels

Weston, J., Leslie, C., Zhou, D., Elisseeff, A., & Noble, W. (2004). Semi-Supervised Protein Classification using Cluster Kernels. Advances in Neural Information Processing Systems 16, 595-602.

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 Urheber:
Weston, J1, 2, Autor           
Leslie, C, Autor
Zhou, D1, 2, Autor           
Elisseeff, A1, 2, Autor           
Noble, WS, Autor
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Zusammenfassung: A key issue in supervised protein classification is the representation of input sequences of amino acids. Recent work using string kernels for protein data has achieved state-of-the-art classification performance. However, such representations are based only on labeled data --- examples with known 3D structures, organized into structural classes --- while in practice, unlabeled data is far more plentiful. In this work, we develop simple and scalable cluster kernel techniques for incorporating unlabeled data into the representation of protein sequences. We show that our methods greatly improve the classification performance of string kernels and outperform standard approaches for using unlabeled data, such as adding close homologs of the positive examples to the training data. We achieve equal or superior performance to previously presented cluster kernel methods while achieving far greater computational efficiency.

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 Datum: 2004-06
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: BibTex Citekey: 2336
 Art des Abschluß: -

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Titel: Seventeenth Annual Conference on Neural Information Processing Systems (NIPS 2003)
Veranstaltungsort: Vancouver, BC, Canada
Start-/Enddatum: 2003-12-09 - 2003-12-11

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Titel: Advances in Neural Information Processing Systems 16
Genre der Quelle: Zeitschrift
 Urheber:
Thrun, S, Herausgeber
Saul, LK, Herausgeber
Schölkopf, B1, Herausgeber           
Affiliations:
1 Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794            
Ort, Verlag, Ausgabe: Cambridge, MA, USA : MIT Press
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: 595 - 602 Identifikator: ISBN: 0-262-20152-6