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Abstract:
The blood oxygenation level dependent (BOLD) signal depends on physiological changes which affect the signal behavior of protons both in the intra- and
extravascular tissue space. The functional dependency of the extravascular signal on the oxygenation fraction Y and on cerebral blood volume (CBV) can
currently only be evaluated by numerical simulations. We provide analytical expressions for relaxation rates R2* and R2 depending on Y, B0 up to 9.4 T,
and CBV for different size cylinders (approx. 3, 6, 20 μm). These results allow to model stimulus evoked BOLD signal changes for GRE and SE at different
field strengths.
