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Abstract:
MR contrast agents whose efficiency depends on the concentration of signaling
molecules may be used to directly visualize neuronal activation. The so-called ‘smart’
contrast agents for magnetic resonance imaging exhibit dynamic and reversible
modulation of their relaxivity by specific physiological or biochemical triggers such as
changes in pH, Ca2+ concentration or enzymatic activity. The extracellular concentration
of Ca2+ plays an important role in the
physiological and pathological processes
of the nervous system; it led us to design
chelating systems in which the relaxivity
is influenced by the Ca2+ concentration.
We synthesized three novel bifunctional
bismacrocycles based on DO3A-EA
coupled to EDTA/DTPA-bisanhydride
via amide bonds.
