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Schlagwörter:
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Zusammenfassung:
The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its
development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in
mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal
telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The
CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin
and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial
glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid
nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link
between the amygdala and the neocortex.
