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  Negative BOLD Signal Under 6 Hypercapnia Reflects Solely Oxygen Extraction from the Blood

Zappe, A.-C., Uludag, K., & Logothetis, N. (2008). Negative BOLD Signal Under 6 Hypercapnia Reflects Solely Oxygen Extraction from the Blood. In 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008) (pp. 166).

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-C99D-E Version Permalink: https://hdl.handle.net/21.11116/0000-0003-92FA-E
Genre: Meeting Abstract

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https://cds.ismrm.org/ismrm-2008/files/1_program.pdf (Abstract)
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 Creators:
Zappe, A-C1, 2, Author           
Uludag, K2, 3, Author           
Logothetis, NK1, 2, Author           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              

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 Abstract: The BOLD signal is sensitive to cerebral blood flow (CBF), blood volume (CBV) and oxygen extraction. In the anesthetized monkey, we observe a vasodilatory ceiling effect during inhalation of 6 CO2 where CBF or CBV are not further increased by visual stimulation. In contrast, simultaneously measured local field potential responds to the stimulation as strong as during normocapnia. As a consequence, the stimulus-induced fMRI response during
6 hypercapnia has been found to be negative reflecting only the oxygen extraction from the blood. With this method, oxygen extraction can be imaged by means of fMRI without injection of an exogenous drug.

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 Dates: 2008-05
 Publication Status: Issued
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 Identifiers: BibTex Citekey: ZappeUL2008
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Title: 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008)
Place of Event: Toronto, Canada
Start-/End Date: 2008-05-03 - 2008-05-09

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Title: 16th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 850 Start / End Page: 166 Identifier: -