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  Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations

Angelovski, G., Fousková P, Mamedov, I., Canals, S., Tóth, É., & Logothetis, N. (2008). Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations. ChemBioChem, 9(11), 1729-1734. doi:10.1002/cbic.200800165.

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 Creators:
Angelovski, G1, Author           
Fousková P, Mamedov, I1, Author           
Canals, S2, Author           
Tóth, É, Author
Logothetis, NK1, Author           
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1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Gd3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca2+ fluctuations in the brain Gd3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca2+ fluctuations in the brain. Upon interaction with Ca2+, they exhibit high and reversible relaxivity changes in buffered solution or in a model of the brain extracellular medium. These efficient Ca2+ magnetic resonance imaging sensors might open new perspectives in functional molecular imaging.

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 Dates: 2008-07
 Publication Status: Issued
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Title: ChemBioChem
Source Genre: Journal
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Pages: - Volume / Issue: 9 (11) Sequence Number: - Start / End Page: 1729 - 1734 Identifier: -