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キーワード:
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要旨:
The measurement of cerebral metabolic rate of oxygen (CMRO2) via direct NMR detection of the stable oxygen
isotope 17O is a promising tool to study alterations in brain activity and pathology. Due to the low natural
abundance of 0.037 H2O17, optimized acquisition parameters are crucial for 17O-weigthed MRI of metabolically
produced cerebral water. It has been suggested that signal-to-noise ratio increases almost quadratically with B0
due to field-independent quadrupolar interactions of 17O. Thus, in comparison to studies at lower field strengths the increased magnetization available at 16.4 T allows an enhanced spatial resolution and thus for the first time a tissue-specific determination of 17O relaxation.
