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Abstract:
A novel and fast approach for passive real-time tracking of interventional devices using paramagnetic markers, termed “projection-reconstruction imaging with echo-dephasing” (PRIDE) is presented. PRIDE is based on the acquisition of echo-dephased projections along all three physical axes. Dephasing is preferably set to 4π within each projection ensuring that background tissues do not contribute to signal formation and thus appear heavily suppressed. However, within the close vicinity of the paramagnetic marker, local gradient fields compensate for the intrinsic dephasing to form an echo. Successful localization of the paramagnetic marker with PRIDE is demonstrated in vitro and in vivo in the presence of different types of off-resonance (air/tissue interfaces, main magnetic field inhomogeneities, etc). In order to utilize the PRIDE sequence for vascular interventional applications, it was interleaved with balanced steady-state free precession (bSSFP) to provide positional updates to the imaged slice using a dedicated real-time feedback link. Active slice positioning (ASP) with PRIDE is demonstrated in vitro, requiring approximately 20 ms for the positional update to the imaging sequence, comparable to existing active tracking methods.
