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  Imaging the dynamics of mammalian neocortical population activity in-vivo

Grinvald, A., Omer, D., Naaman, S., & Sharon, D. (2010). Imaging the dynamics of mammalian neocortical population activity in-vivo. In M. Canepari, & D. Zecevic (Eds.), Membrane potential imaging in the nervous system: methods and applications (pp. 97-111). New York, NY, USA: Springer.

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Grinvald, A, Author
Omer, DB1, Author           
Naaman, S, Author
Sharon, D, Author
Affiliations:
1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel, ou_persistent22              

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 Abstract: Neural computations underlying sensory perception, cognition, and motor control are performed by populations of neurons at different anatomical and temporal scales. Few techniques are currently available for exploring dynamics of local and large range populations. Voltage-sensitive dye imaging (VSDI) reveals neural population activity in areas ranging from a few tens of microns to a couple of centimeters, or two areas up to ∼10 cm apart. VSDI provides a sub-millisecond temporal resolution, and a spatial resolution of about 50 µm. The dye signal emphasizes subthreshold synaptic potentials. VSDI has been applied in the mouse, rat, gerbil, ferret, tree shrew, cat, and monkey cortices, in order to explore lateral spread of retinotopic or somatotopic activation, the dynamic spatiotemporal pattern resulting from sensory activation, including the somatosensory, olfactory, auditory, and visual modalities, as well as motor preparation and the properties of spontaneously occurring population activity. In this chapter we focus on VSDI in vivo and review the results obtained mostly in the visual system in our laboratory.

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 Dates: 2010-09
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1007/978-1-4419-6558-5_9
BibTex Citekey: GrinvaldONS2010
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Title: Membrane potential imaging in the nervous system: methods and applications
Source Genre: Book
 Creator(s):
Canepari, M, Editor
Zecevic, D, Editor
Affiliations:
-
Publ. Info: New York, NY, USA : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 97 - 111 Identifier: ISBN: 978-1-441-96557-8