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  In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration

Mamedov, I., Canals, S., Henig, J., Beyerlein, M., Murayama, Y., Mayer, H., et al. (2010). In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration. ACS Chemical Neuroscience, 1(12), 819-828. doi:10.1021/cn100083a.

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Mamedov, I1, 2, Author           
Canals, S1, 2, Author           
Henig, J, Author
Beyerlein, M1, 2, Author           
Murayama, Y1, 2, Author           
Mayer, HA, Author
Logothetis, NK1, 2, Author           
Angelovski, G1, 2, Author           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Contrast agents for magnetic resonance imaging (MRI) that exhibit sensitivity toward specific ions or molecules represent a challenging but attractive direction of research. Here a Gd3+ complex linked to an aminobis(methylenephosphonate) group for chelating Ca2+ was synthesized and investigated. The longitudinal relaxivity (r1) of this complex decreases during the relaxometric titration with Ca2+ from 5.76 to 3.57 mMamp;amp;8722;1 samp;amp;8722;1 upon saturation. The r1 is modulated by changes in the hydration number, which was confirmed by determination of the luminescence emission lifetimes of the analogous Eu3+ complex. The initial in vivo characterization of this responsive contrast agent was performed by means of electrophysiology and MRI experiments. The investigated complex is fully biocompatible, having no observable effect on neuronal function after administration into the brain ventricles or parenchyma. Distribution studies demonstrated that the diffusivity
of this
agent is
significantly lower compared with that of gadoliniumamp;amp;8722;diethylenetriaminepentaacetic acid (Gdamp;amp;8722;DTPA).

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 Dates: 2010-12
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1021/cn100083a
BibTex Citekey: 6854
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Title: ACS Chemical Neuroscience
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 1 (12) Sequence Number: - Start / End Page: 819 - 828 Identifier: ISSN: 1948-7193
CoNE: https://pure.mpg.de/cone/journals/resource/1948-7193