Emotional Processing And Brain Metabolism After Pharmacological Stimulation 
With Ketamine: Implications For Major Depression

Scheidegger, M; Henning, A; Fuchs, A; Krähenmann, R; Böker, H; Bösiger, P; Seifritz, E; Walter, M; Grimm, S

doi:10.1016/j.biopsych.2011.03.031

Emotional Processing And Brain Metabolism After Pharmacological Stimulation With Ketamine: Implications For Major Depression

Scheidegger, M., Henning, A., Fuchs, A., Krähenmann, R., Böker, H., Bösiger, P., Seifritz, E., Walter, M., & Grimm, S. (2011). Emotional Processing And Brain Metabolism After Pharmacological Stimulation With Ketamine: Implications For Major Depression. Poster presented at 66th Society of Biological Psychiatry Annual Meeting 2011, San Francisco, CA, USA.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-0013-BBF6-2 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0002-4FB2-D

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作成者:
Scheidegger, M, 著者
Henning, A¹, 著者
Fuchs, A, 著者
Krähenmann, R, 著者
Böker, H, 著者
Bösiger, P, 著者
Seifritz, E, 著者
Walter, M, 著者
Grimm, S, 著者

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1ETH and University Zürich, ou_persistent22

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要旨: Background / Purpose:
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at subanaesthetic doses, thus providing a valuable research tool for the investigation of the neurobiology of major depressive disorder (MDD).
This multimodal imaging study in 23 healthy subjects reveals the neuropharmacological effects of a single intravenous subanaesthetic ketamine infusion on fMRI-BOLD responses during an emotional processing task and their relationship to glutamatergic metabolite concentrations in the pregenual anterior cingulate cortex (PACC) assessed by proton magnetic resonance spectroscopy (1H-MRS).
Main conclusion:
Our findings show that ketamine has the potential to increase negative BOLD responses (NBRs) in PACC, which have been found to be decreased in MDD patients during an emotional processing task. A correlation between glutamate/glutamine ratios as a putative spectroscopic marker of glutamatergic neurotransmission and task associated NBRs could be found after ketamine administration compared to baseline.
Our multimodal findings suggest that the increased NBRs observed during ketamine infusion are most likely interpreted in terms of an increased baseline brain metabolism due to an increase in the glutamate-glutamine-cycling rate. Hence, the antidepressant effect of ketamine might be linked to a beneficial short-term influence on glutamatergic neurotransmission and cerebral neuroenergetics.
Next steps:
The same research protocol will be applied for MDD patients.

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日付: 出版: 2011-05

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識別子（DOI, ISBNなど）: BibTex参照ID: ScheideggerHFKBBSWG2011
DOI: 10.1016/j.biopsych.2011.03.031

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出版物名: Biological Psychiatry

その他 : Biol. Psychiatry

種別: 学術雑誌

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出版社, 出版地: New York : Elsevier

ページ: - 巻号: 69 (9 Supplement) 通巻号: 580 開始・終了ページ: 175 識別子（ISBN, ISSN, DOIなど）: ISSN: 0006-3223
CoNE: https://pure.mpg.de/cone/journals/resource/954925384111

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