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  Nocturnal secretion of TSH and ACTH in male patients with depression and healthy controls

Peteranderl, C., Antonijevic, I., Steiger, A., Murck, H., Held, K., Frieboes, R., et al. (2002). Nocturnal secretion of TSH and ACTH in male patients with depression and healthy controls. Journal of Psychiatric Research, 36(3), 189-196.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A1ED-C Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A1EE-A
Genre: Zeitschriftenartikel
Alternativer Titel : J. Psychiatr. Res.

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 Urheber:
Peteranderl, C1, Autor
Antonijevic, IA1, Autor
Steiger, A1, Autor
Murck, H1, Autor
Held, K1, Autor
Frieboes, RM1, Autor
Uhr, M1, Autor
Schaaf, L1, Autor
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Schlagwörter: thyroid axis; adrenal axis; TSH; ACTH; affective disorder; sleep
 Zusammenfassung: profound alterations of the hypothalamic-pituitary-thyroid (HPT) and the hypothalamic-pituitary-adrenal (HPA) systems at the hypophyseal level have been described in affective disorder. To precisely characterize the basal alterations of both axes during sleep. we simultaneously investigated sleep EEG and the secretion of thyrotropin. ACTH and cortisol in nine drug-free male patients with depression in comparison to 10 healthy age and sex matched controls. In depressed patients the nearly diametrical nocturnal secretion of thyrotropin and ACTH was disturbed by significantly blunted thyrotropin values (TSH AUC 51.96+/-5.68 vs. 87.23+/-13.63. P<0.05) and elevated ACTH values (ACTH AUC 1804+/-161 vs. 1538+/-130. P<0.05) compared to controls. Moreover, cross correlation analysis revealed a highly negative association of 0 lag between thyrotropin and ACTH and between thyrotropin and cortisol in the control sample, indicating a physiological nocturnal negative correlation of HPT and HPA system. In the patients sample these associations were weak and reached not statistical significance. Therefore, as a descriptive tool, the ratio TSH/ACTH revealed a significant group difference between controls and patients in the first half of the night (TSH/ACTH AUC 6.50+/-0.42 vs. 3.35+/-0.31. P<0.05). Sleep-EEG analysis showed a shortened REM latency, a decrease of stage 2 and an increase of awake time in the patients. Our data support the hypothesis that both hypophyseal hormones reflect a common dysregulation of both systems in depression probably due to impaired action of TRH-related corticotropin-release- inhibiting-factor (CRIF). The ratio TSH/ACTH might be a tool to characterize alterations of both the HPT and HPA axis in depression during the first half of the night, (C), 2002 Elsevier Science Ltd. All rights reserve

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Sprache(n): eng - English
 Datum: 2002-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 4157
ISI: 000175643300010
 Art des Abschluß: -

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Titel: Journal of Psychiatric Research
  Alternativer Titel : J. Psychiatr. Res.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 36 (3) Artikelnummer: - Start- / Endseite: 189 - 196 Identifikator: ISSN: 0022-3956