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  Nerve growth factor and retinoic acid interactions in the control of small cell lung cancer proliferation

Fiorentini, C., Facchetti, M., Finardi, A., Sigala, S., Paez-Pereda, M., Sher, E., Spano, P., & Missale, C. (2002). Nerve growth factor and retinoic acid interactions in the control of small cell lung cancer proliferation. European Journal of Endocrinology, 147(3), 371-379.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000E-A18D-4 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000E-A18E-2
資料種別: 学術論文
その他のタイトル : Eur. J. Endocrinol.

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 作成者:
Fiorentini, C1, 著者
Facchetti, M1, 著者
Finardi, A1, 著者
Sigala, S1, 著者
Paez-Pereda, M1, 著者
Sher, E1, 著者
Spano, PF1, 著者
Missale, C1, 著者
所属:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

内容説明

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キーワード: -
 要旨: Objective: Nerve growth factor (NGF) has antiproliferative and differentiating effects in neuroendocrine tumors. In cell lines derived from small cell lung cancer (SCLC), NGF treatment stimulates NGF receptor expression, activates NGF secretion, inhibits proliferation and abrogates invasion. Since these effects are lost upon NGF withdrawal, it is relevant to identify other differentiation factors that may co-operate with the NGF system to control SCLC growth and differentiation. Design: Retinoic acid (RA), which has been shown to inhibit cell transformation and proliferation, modulates the expression of NGF receptors and the sensitivity to NGF in different cell models. In the present study, we have investigated whether NGF and RA may interact to control the proliferation of SCLC cell lines. Methods: SCLC cells were exposed to 50 ng/ml NGF or 1 muM all-trans RA for different times. Cell proliferation was measured by the [H-3]thymidine incorporation test and NGF receptor expression was evaluated by immunofluorescence. Results: We found that RA increased the expression of both trkA and p75 NGF receptors in NCl-N-592 and GLC8 cell lines and prevented the loss of both NGF production and NGF receptor expression occurring when NGF treatment was discontinued. As a result, RA, which did not inhibit the proliferation of untreated cells, abolished NGF withdrawal-related increase in cell proliferation both in vitro and in vivo, thus making permanent the antiproliferative effects of NGF. Conclusions: These data suggest that combined treatments with NGF and RA or mimicking drugs may represent a strategy to be further investigated for the treatment of SCLC

資料詳細

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言語: eng - English
 日付: 2002-09
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: eDoc: 4050
ISI: 000178743900013
 学位: -

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出版物 1

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出版物名: European Journal of Endocrinology
  出版物の別名 : Eur. J. Endocrinol.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 147 (3) 通巻号: - 開始・終了ページ: 371 - 379 識別子（ISBN, ISSN, DOIなど）: ISSN: 0804-4643