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  Microstructure of the non-rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: Effects of Dopaminergic treatment

Brunner, H., Wetter, T., Hoegl, B., Yassouridis, A., Trenkwalder, C., & Friess, E. (2002). Microstructure of the non-rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: Effects of Dopaminergic treatment. Movement Disorders, 17(5), 928-933.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A187-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A188-E
Genre: Journal Article
Alternative Title : Mov. Disord.

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 Creators:
Brunner, H1, Author
Wetter, TC1, Author
Hoegl, B1, Author
Yassouridis, A1, Author
Trenkwalder, C1, Author
Friess, E1, Author
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Free keywords: Parkinson''s disease; quantitative EEG; EEG power spectrum; non- REM sleep; delta power; dopamine
 Abstract: We investigated non-rapid eye movement (non-REM) sleep in patients with newly diagnosed Parkinson''s disease (PD) who had never previously received dopaminergic medication. There were no significant differences in the conventional sleep parameters between de novo patients with PD and a healthy control group, but the length of stage I sleep and the number of awakenings increased significantly upon administration of dopaminergic drugs. Analyzing the quantitative electroencephalogram (EEG), we observed a significant reduction in the low-delta frequency range and a nonsignificant increase in the sigma frequency range in de novo patients with PD. The dopaminergic medication also nonsignificantly reduced the low-delta and sigma frequencies, the latter to the level of the controls. Possible mechanisms that may account for the observed differences are discussed. It is suggested that Parkinson''s disease as well as the application of dopaminergic drugs exerts a desynchronizing effect on the sleep EEG that is reflected in a disruption of sleep continuity. (C) 2002 Movement Disorder Society

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Language(s): eng - English
 Dates: 2002-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 4073
ISI: 000178384400008
 Degree: -

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Title: Movement Disorders
  Alternative Title : Mov. Disord.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 17 (5) Sequence Number: - Start / End Page: 928 - 933 Identifier: ISSN: 0885-3185