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  Repetitive transcranial magnetic stimulation (rTMS) in major depression: Relation between efficacy and stimulation intensity

Padberg, F., Zwanzger, P., Keck, M., Kathmann, N., Mikhaiel, P., Ella, R., Rupprecht, P., Thoma, H., Hampel, H., Toschi, N., & Möller, H. (2002). Repetitive transcranial magnetic stimulation (rTMS) in major depression: Relation between efficacy and stimulation intensity. Neuropsychopharmacology, 27(4), 638-645.

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資料種別: 学術論文
その他のタイトル : Neuropsychopharmacology

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 作成者:
Padberg, F1, 著者
Zwanzger, P1, 著者
Keck, ME1, 著者
Kathmann, N1, 著者
Mikhaiel, P1, 著者
Ella, R1, 著者
Rupprecht, P1, 著者
Thoma, H1, 著者
Hampel, H1, 著者
Toschi, N1, 著者
Möller, HJ1, 著者
所属:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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キーワード: major depression; medication resistance; affective disorders; transcranial magnetic stimulation; stimulation intensity; current density; dorsolateral prefrontal cortex
 要旨: Repetitive transcranial magnetic stimulation (rTMS) has been found to exert modest to substantial antidepressant effects in the majority of prior clinical studies. As effect sizes and stimulation conditions have varied greatly, controversy persists regarding effective stimulation parameters (e.g. intensity, frequcncy, localization). In the present controlled study, we investigated whether the antidepressant efficacy of rTMS may be related to the stimulation intensity applied. Thirty-one patients suffering from a pharmacotherapy-resistant major depressive episode were randomly assigned to three treatment groups receiving rTMS at different stimulation intensities: (1) intensity at the individual motor threshold (MT); (2) 90% subthreshold intensity; and (3) low intensity of standard sham rTMS. Each patient underwent 10 sessions of 10 Hz rTMS with 1500 stimuli/day over the left dorsolateral prefrontal cortex. Improvement of depressive symptoms after rTMS significantly increased with stimulation intensity across the three groups. A 30% to 33% reduction of baseline depression scores was observed after rTMS at MT intensity. Similarly, groups differed significantly regarding the clinical course after rTMS with the lowest number of antidepressant interventions and the shortest hospital stay in the MT intensity group. These findings support the hypothesis of a relationship between stimulation intensity of rTMS and its antidepressant efficac

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言語: eng - English
 日付: 2002-10
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): eDoc: 4091
ISI: 000177983700013
 学位: -

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出版物 1

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出版物名: Neuropsychopharmacology
  出版物の別名 : Neuropsychopharmacology
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 27 (4) 通巻号: - 開始・終了ページ: 638 - 645 識別子(ISBN, ISSN, DOIなど): ISSN: 0893-133X