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  The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol

Spanagel, R., Siegmund, S., Cowen, M., Schroff, K., Schumann, G., Fiserova, M., Sillaber, I., Wellek, S., Singer, M., & Putzke, J. (2002). The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol. Journal of Neuroscience, 22(19), 8676-8683.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000E-A137-6 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000E-A138-4
資料種別: 学術論文
その他のタイトル : J. Neurosci.

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 作成者:
Spanagel, R1, 著者
Siegmund, S1, 著者
Cowen, M1, 著者
Schroff, KC1, 著者
Schumann, G1, 著者
Fiserova, M1, 著者
Sillaber, I1, 著者
Wellek, S1, 著者
Singer, M1, 著者
Putzke, J1, 著者
所属:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

内容説明

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キーワード: neuronal nitric oxide synthase; nNOS; nNOS splice variants; knock-out mice; alcohol drinking; taste differences; loss of righting reflex; rapid tolerance; NOS inhibitors
 要旨: In the present study, we describe a new role of the neuronal nitric oxide synthase (nNOS) gene in the regulation of alcohol drinking behavior. Mice deficient in the nNOS gene (nNOS-/-) and wild-type control mice were submitted to a two-bottle free- choice procedure with either water or increasing concentrations of alcohol (2-16%) for 6 weeks. nNOS-/- mice did not differ in consumption and preference for low alcohol concentrations from wild-type animals; however, nNOS-/- mice consumed sixfold more alcohol from highly concentrated alcohol solutions than wild- type mice. Taste studies with either sucrose or quinine solutions revealed that alcohol intake in nNOS -/- and wild- type mice is associated, at least in part, with sweet solution intake but not with the taste of bitterness. When compared with wild-type mice, the nNOS-/- mice were found to be less sensitive to the sedative effects of ethanol as measured by shorter recovery time from ethanol-induced sleep and did not develop rapid tolerance to ethanol-induced hypothermia, although plasma ethanol concentrations were not significantly different from those of controls. Our findings contrast with previous reports that showed that nonselective NOS inhibitors decrease alcohol consumption. However, because alcohol consumption was suppressed in wild-type as well as nNOS -/- mice by the NOS inhibitor N-G-nitro-L-arginine methyl ester, we conclude that the effect of nonselective NOS inhibitors on alcohol drinking is not mediated by nNOS. Other NOS isoforms, most likely in the periphery or other splice variants of the NOS gene, might contribute to the effect of nonselective NOS inhibitors on alcohol drinking. In summary, the nNOS gene is critically involved in the regulation of neurobehavioral effects of alcoho

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言語: eng - English
 日付: 2002-10-01
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: eDoc: 4077
ISI: 000178246000036
 学位: -

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出版物 1

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出版物名: Journal of Neuroscience
  出版物の別名 : J. Neurosci.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 22 (19) 通巻号: - 開始・終了ページ: 8676 - 8683 識別子（ISBN, ISSN, DOIなど）: ISSN: 0270-6474