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  The macrophage activity marker sCD14 is increased in patients with multiple sclerosis and upregulated by interferon beta-1b

Brettschneider, J., Ecker, D., Bitsch, A., Bahner, D., Bogumil, T., Dressel, A., et al. (2002). The macrophage activity marker sCD14 is increased in patients with multiple sclerosis and upregulated by interferon beta-1b. Journal of Neuroimmunology, 133(1-2), 193-197.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A003-F Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A004-D
Genre: Zeitschriftenartikel
Alternativer Titel : J. Neuroimmunol.

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 Urheber:
Brettschneider, J.1, Autor
Ecker, D1, Autor
Bitsch, A1, Autor
Bahner, D1, Autor
Bogumil, T1, Autor
Dressel, A1, Autor
Elitok, E1, Autor
Kitze, B1, Autor
Poser, S1, Autor
Weber, F1, Autor
Tumani, H.1, Autor
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

Inhalt

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Schlagwörter: multiple sclerosis; primary progressive; relapsing remitting; macrophage activity; sCD14; interferon beta
 Zusammenfassung: The soluble form of the CD14 molecule (sCD14), a macrophage activity marker, was measured in the plasma of 17 patients with primary progressive multiple sclerosis (PPMS) and 20 patients with relapsing remitting MS (RRMS). In patients with PPMS, sCD14 levels were determined before and after treatment with interferon beta (IFNB). In both PPMS and in RRMS, sCD14 levels were significantly elevated compared to healthy controls. In patients with PPMS, sCD14 levels increased significantly during the first 3 months of IFNB therapy, then slightly decreased, but still remained elevated compared with levels before therapy. Therefore, the elevated sCD14 levels may be a marker in evaluating biological response to IFNB therapy. (C) 2002 Elsevier Science B.V. All rights reserved

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Sprache(n): eng - English
 Datum: 2002-12
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 4025
ISI: 000179874700020
 Art des Abschluß: -

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Titel: Journal of Neuroimmunology
  Alternativer Titel : J. Neuroimmunol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 133 (1-2) Artikelnummer: - Start- / Endseite: 193 - 197 Identifikator: ISSN: 0165-5728