Steps toward mapping the human vasculature by phage display

Arap, Wadih; Kolonin, Mikhail G.; Trepel, Martin; Lahdenranta, Johanna; Cardó-Vila, Marina; Giordano, Ricardo J.; Mintz, Paul J.; Ardelt, Peter U.; Yao, Virginia J.; Vidal, Claudia I.; Chen, Limor; Flamm, Anne; Valtanen, Heli; Weavind, Lisa M.; Hicks, Marshall E.; Pollock, Raphael E.; Botz, Gregory H.; Bucana, Corazon D.; Koivunen, Erkki; Cahill, Dolores; Troncoso, Patricia; Baggerly, Keith A.; Pentz, Rebecca D.; Do, Kim-Anh; Logothetis, Christopher J.; Pasqualin, Renata

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Steps toward mapping the human vasculature by phage display

Arap, W., Kolonin, M. G., Trepel, M., Lahdenranta, J., Cardó-Vila, M., Giordano, R. J., et al. (2002). Steps toward mapping the human vasculature by phage display. Nature Medicine, 8(2), 121-127.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8B7B-3 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8B7C-1

Genre: Zeitschriftenartikel

Alternativer Titel : Nat Med

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Arap, Wadih, Autor
Kolonin, Mikhail G., Autor
Trepel, Martin, Autor
Lahdenranta, Johanna, Autor
Cardó-Vila, Marina, Autor
Giordano, Ricardo J., Autor
Mintz, Paul J., Autor
Ardelt, Peter U., Autor
Yao, Virginia J., Autor
Vidal, Claudia I., Autor
Chen, Limor, Autor
Flamm, Anne, Autor
Valtanen, Heli, Autor
Weavind, Lisa M., Autor
Hicks, Marshall E., Autor
Pollock, Raphael E., Autor
Botz, Gregory H., Autor
Bucana, Corazon D., Autor
Koivunen, Erkki, Autor
Cahill, Dolores¹, Autor
Troncoso, Patricia, AutorBaggerly, Keith A., AutorPentz, Rebecca D., AutorDo, Kim-Anh, AutorLogothetis, Christopher J., AutorPasqualin, Renata, Autor mehr..

Affiliations:
1Max Planck Society, ou_persistent13

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Zusammenfassung: The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a peptide library. Here we report the first in vivo screening of a peptide library in a patient. We surveyed 47,160 motifs that localized to different organs. This large-scale screening indicates that the tissue distribution of circulating peptides is nonrandom. High-throughput analysis of the motifs revealed similarities to ligands for differentially expressed cell-surface proteins, and a candidate ligand–receptor pair was validated. These data represent a step toward the construction of a molecular map of human vasculature and may have broad implications for the development of targeted therapies.

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Sprache(n): eng - English

Datum: Erschienen: 2002-11-02

Publikationsstatus: Erschienen

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Identifikatoren: eDoc: 24729

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Titel: Nature Medicine

Alternativer Titel : Nat Med

Genre der Quelle: Zeitschrift

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Seiten: - Band / Heft: 8 (2) Artikelnummer: - Start- / Endseite: 121 - 127 Identifikator: -

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