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  Array technology and proteomics in autoimmune diseases

Krenn, V., Petersen, I., Haeupl, T., Koepenik, A., Blind, C., Dietel, M., et al. (2004). Array technology and proteomics in autoimmune diseases. Proteomics in Pathology, Research and Practice, 95-103. doi:10.1016/j.prp.2004.02.005.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8861-6 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8862-4
Genre: Journal Article
Alternative Title : Pathol., Res. Pract.

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 Creators:
Krenn, Veit, Author
Petersen, Iver, Author
Haeupl, Thomas, Author
Koepenik, Axel, Author
Blind, Christiane, Author
Dietel, Manfred, Author
Konthur, Zoltan1, Author
Skriner, Karl, Author
Affiliations:
1Max Planck Society, ou_persistent13              

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Free keywords: Tissue array; Proteomics; Rheumatoid arthritis; Osteoarthritis; Synovitis score
 Abstract: Two new technologies (tissue microarrays (TMAs) and proteomics) have generated a great amount of data in life science. High-density TMAs allow for the simultaneous analysis of proteins and RNA by various methods (immunohistochemistry, in situ hybridization, FISH) on a large scale and under highly standardized conditions. Proteomics includes a variety of techniques that are partly high throughput. These techniques aim at the innovation of proteins, the description of the domain structure, the determination of protein sequences and epitope characterization, and ultimately the definition of protein function and protein reactivities in immunologic processes. Proteins that have been characterized accordingly require validation mostly at the morphologic level of defined tissue, linking proteomics to TMAs. In autoimmune diseases, array-based antigenic fingerprinting of autoantibodies will drive the development and the selection of antigen-specific diagnostic tools and therapies. The powerful combination of genomics and proteomics formed in tissue arrays has the potential to change the way the biology of autoimmunity is studied. Novel targets of drug discovery, based on antigen-specific therapies to induce anergy, or regulatory T-cells using the targeted autoantigens of individual patients could be developed in the coming decades.

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Language(s): eng - English
 Dates: 2004-04-30
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 229541
DOI: 10.1016/j.prp.2004.02.005
 Degree: -

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Title: Proteomics in Pathology, Research and Practice
Source Genre: Issue
 Creator(s):
Roecken, Christoph, Editor
Affiliations:
-
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 95 - 103 Identifier: -

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Title: Pathology, Research and Practice : Official Journal of the European Society of Pathology
  Alternative Title : Pathol., Res. Pract.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 200 Sequence Number: - Start / End Page: - Identifier: ISSN: 0344-0338