English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  The Type 1 Diabetes Locus Idd6 Controls TLR1 Expression.

Vallois, D., Grimm, C. H., Avner, P., Boitard, C., & Rogner, U. C. (2007). The Type 1 Diabetes Locus Idd6 Controls TLR1 Expression. The Journal of Immunology, 179(6), 3896-3903. Retrieved from http://www.jimmunol.org/cgi/reprint/179/6/3896?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1&FIRSTINDEX=0&sortspec=relevance&firstpage=3896&resourcetype=HWCIT.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-82F3-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-82F4-8
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Vallois, David, Author
Grimm, Christina H.1, Author
Avner, Philip, Author
Boitard, Christian, Author
Rogner, Ute Christine, Author
Affiliations:
1Max Planck Society, ou_persistent13              

Content

show
hide
Free keywords: -
 Abstract: The Idd6 locus on mouse chromosome 6, which controls the development of type 1 diabetes in the NOD mouse, affects proliferation rates of T cells and the activity of regulatory CD4+CD25+ T cells. Using a transcriptional profiling approach, we show that splenocytes and thymocytes from diabetes-resistant Idd6 NOD.C3H-congenic mouse strains exhibit a constitutive and specific down-regulation of Toll-like receptor 1 (Tlr1) gene expression compared with diabetes prone NOD mice. This phenotype correlates with a diminished proliferation capacity of both CD4+CD25– effector and CD4+CD25+ regulatory T cells upon in vitro stimulation of the TLR1/TLR2 pathway by the ligand palmitoyl-3-cysteine-serine-lysine 4, and with the constitutive down-regulation of Tnf-{alpha} and IL-6 in macrophages of Idd6- congenic mice. These data suggest that TLR1 is involved in the regulation of mechanisms that impinge on diabetes development in the NOD mouse

Details

show
hide
Language(s): eng - English
 Dates: 2007
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 366401
URI: http://www.jimmunol.org/cgi/reprint/179/6/3896?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1&FIRSTINDEX=0&sortspec=relevance&firstpage=3896&resourcetype=HWCIT
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: The Journal of Immunology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 179 (6) Sequence Number: - Start / End Page: 3896 - 3903 Identifier: ISSN: 0022-1767