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Free keywords:
Peptide-hydrolyzing activity; Multicatalytic proteinase; Thermoplasma-acidophilum; Yeast proteasome; Structural features; 20s proteasome; Complex; Subunit; Degradation; Proteolysis.; Biochemistry & biophysics.
Abstract:
The proteasome is a macromolecular assembly that is designed to confine proteolytic activity to an inner cavity. Access to the central proteolytic nanocompartment is restricted to unfolded proteins, which necessitates a functional coupling of the 20S proteasome to a substrate-recognition and unfolding machinery. Significant progress has been made during the past two years in elucidating the structural principles and the enzymatic mechanism of the 20S proteasome. [References: 52]
