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  Modulation of neuronal interactions through neuronal synchronization

Womelsdorf, T., Schoffelen, J.-M., Oostenveld, R., Singer, W., Desimone, R., Engel, A. K., et al. (2007). Modulation of neuronal interactions through neuronal synchronization. Science, 316, 1609-1612. doi:10.1126/science.1139597.

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Womelsdorf_Science_2007.pdf (Publisher version), 385KB
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Womelsdorf_Science_2007.pdf
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Womelsdorf, Thilo1, Author
Schoffelen, Jan-Mathijs1, Author           
Oostenveld, Robert1, Author
Singer, Wolf2, 3, Author
Desimone, Robert4, 5, Author
Engel, Andreas K.6, Author
Fries, Pascal1, 7, Author
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, ou_55236              
2Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt, Germany. , ou_persistent22              
3Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University, ou_persistent22              
4Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD , ou_persistent22              
5McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA , ou_persistent22              
6Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, ou_persistent22              
7Department of Biophysics, Radboud University Nijmegen, Netherlands, ou_persistent22              

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 Abstract: Brain processing depends on the interactions between neuronal groups. Those interactions are governed by the pattern of anatomical connections and by yet unknown mechanisms that modulate the effective strength of a given connection. We found that the mutual influence among neuronal groups depends on the phase relation between rhythmic activities within the groups. Phase relations supporting interactions between the groups preceded those interactions by a few milliseconds, consistent with a mechanistic role. These effects were specific in time, frequency, and space, and we therefore propose that the pattern of synchronization flexibly determines the pattern of neuronal interactions.

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Language(s): eng - English
 Dates: 2007
 Publication Status: Issued
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.1139597
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Title: Science
Source Genre: Journal
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Publ. Info: American Association for the Advancement of Science
Pages: - Volume / Issue: 316 Sequence Number: - Start / End Page: 1609 - 1612 Identifier: -