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  Mass Spectrometric Studies of DNA Adducts from a Reaction with Terpenoids

Schrader, W., Döring, S., & Joppek, W. (2004). Mass Spectrometric Studies of DNA Adducts from a Reaction with Terpenoids. Angewandte Chemie International Edition, 43(48), 6657-6660. doi:10.1002/anie.200461022.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-9787-C Version Permalink: https://hdl.handle.net/21.11116/0000-0006-FA5B-B
Genre: Journal Article

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 Creators:
Schrader, Wolfgang1, Author           
Döring, Sven1, Author           
Joppek, Werner1, Author           
Affiliations:
1Service Department Schrader (MS), Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445629              

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Free keywords: DNA; i-spots; mass spectrometry; terpenoids
 Abstract: Markers by mass: The effect of terpenoids on organisms can be investigated by using DNA adducts as markers. High‐resolution MS was used to characterize DNA/α‐pinene oxide adducts after enzymatic digestion. The reaction of α‐pinene oxide with the N7 position of guanosine leads to cleavage of the N‐glycosidic bond and formation of the N7 guanine adducts (see picture).

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Language(s): eng - English
 Dates: 2004-06-212004-12-092004-12-10
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.200461022
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 43 (48) Sequence Number: - Start / End Page: 6657 - 6660 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851