ausblenden:
Schlagwörter:
asymmetric catalysis; chiral phosphoric acid; dynamic kinetic resolution; hydrophosphonylation; organocatalysis
Zusammenfassung:
As mimics of α‐amino acids, α‐amino phosphonates have great promise as antibacterial and anti‐HIV agents as well as protease inhibitors. Racemic α‐branched aldehydes react, in the presence the new chiral phosphoric acid catalyst 1, directly with p‐anisidine (PMPNH2) and a phosphite to furnish β‐branched α‐amino phosphonates highly diastereoselectively and enantioselectively.
