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キーワード:
Brønsted acid catalysis; cyclic N,O-acetals; organocatalysis; N-phosphinyl phosphoramides
要旨:
Fine‐tuning the sites: The readily accessible N‐phosphinyl phosphoramide 1 proved to be highly efficient and enantioselective in catalyzing the title reaction. The synthetic utility of this methodology was demonstrated with the first catalytic asymmetric synthesis of the analgesic pharmaceutical (R)‐chlorothenoxazine (see scheme).
