A new measure for functional similarity of gene products based on Gene Ontology

Schlicker, Andreas; Domingues, Francisco S.; Rahnenführer, Jörg; Lengauer, Thomas

A new measure for functional similarity of gene products based on Gene Ontology

Schlicker, A., Domingues, F. S., Rahnenführer, J., & Lengauer, T. (2006). A new measure for functional similarity of gene products based on Gene Ontology. BMC Bioinformatics, 7, 1-16.

Item is 公開

表示: 全項目非表示: 全項目

基本情報

表示: 非表示:

アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000F-2206-E 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-000F-2207-C

資料種別: 学術論文

ファイル

表示: ファイル

非表示: ファイル

:

Schlicker_BMCBioinformatics_2006.pdf (全文テキスト（全般）), 2MB

ファイルのパーマリンク:
-

ファイル名:
Schlicker_BMCBioinformatics_2006.pdf

説明:
-

OA-Status:

閲覧制限:
非公開

MIMEタイプ / チェックサム:
application/pdf

技術的なメタデータ:

著作権日付:
-

著作権情報:
Copyright 2006 Schlicker et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

CCライセンス:
-

作成者

表示:

非表示:

作成者:
Schlicker, Andreas¹, 著者
Domingues, Francisco S.¹, 著者
Rahnenführer, Jörg¹, 著者
Lengauer, Thomas¹, 著者

所属:
1Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society, ou_40046

内容説明

表示:

非表示:

キーワード: -

要旨: \paragraph*{Background:} Gene Ontology (GO) is a standard vocabulary of functional terms and allows for coherent annotation of gene products. These annotations provide a basis for new methods that compare gene products regarding their molecular function and biological role. \paragraph*{Results:} We present a new method for comparing sets of GO terms and for assessing the functional similarity of gene products. The method relies on two semantic similarity measures; ${\textit sim_{Rel}}$ and ${\textit funSim}$. One measure (${\textit sim_{Rel}}$) is applied in the comparison of the biological processes found in different groups of organisms. The other measure (${\textit funSim}$) is used to find functionally related gene products within the same or between different genomes. Results indicate that the method, in addition to being in good agreement with established sequence similarity approaches, also provides a means for the identification of functionally related proteins independent of evolutionary relationships. The method is also applied to estimating functional similarity between all proteins in Saccharomyces cerevisiae and to visualizing the molecular function space of yeast in a map of the functional space. A similar approach is used to visualize the functional relationships between protein families. \paragraph*{Conclusions:} The approach enables the comparison of the underlying molecular biology of different taxonomic groups and provides a new comparative genomics tool identifying functionally related gene products independent of homology. The proposed map of the functional space provides a new global view on the functional relationships between gene products or protein families.

資料詳細

表示:

非表示:

言語: eng - English

日付: 修正: 2007-03-13出版: 2006

出版の状態: 出版

ページ: -

出版情報: -

目次: -

査読: -

識別子（DOI, ISBNなど）: eDoc: 314476
その他: Local-ID: C125673F004B2D7B-BF59AAAC3C285FAEC12571F500572B63-Schlicker_BMCBioinformatics_2006

学位: -

訴訟

表示:

Project information

表示:

出版物 1

表示:

非表示:

出版物名: BMC Bioinformatics

種別: 学術雑誌

著者・編者:

所属:

出版社, 出版地: -

ページ: - 巻号: 7 通巻号: - 開始・終了ページ: 1 - 16 識別子（ISBN, ISSN, DOIなど）: ISSN: 1471-2105

アイテム詳細

基本情報

ファイル

関連URL

作成者

内容説明

資料詳細

関連イベント

訴訟

Project information

出版物 1